Hotels are, of course, an option. Book in advance, especially in the winter or summer seasons. You can get a room for as cheap as $30/night in South Lake Tahoe, get a package at a casino hotel or spend several hundred dollars a night at one of the many resort style hotels on or near the Lake or ski resorts.
Homeowners in the area do a brisk business renting/leasing out their homes, condos and cabins during the winter and summer seasons. They vary in price from a few hundred dollars/night for a short term rental to $800/mo for a 1-room condo and up to $3,000/mo for 4+ bedroom houses with hot tubs and other amenities. Short term rentals and longer term leases are advertised on local travel and tourism web sites, with real estate agencies as well as in the local papers.
